spinal stenosis

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

---

Study Counts

Type	Study_count
Total_Studies	190
interventional	133
Observational	44
Registry	13

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Procedure	30
Device	24
Drug	22
Other	16
Device|Procedure	7
Drug|placebo	5
Behavioral	3
Behavioral|Other	3
Diagnostic Test	3
Drug|Procedure	3
Other|Procedure	3
Biological|Procedure	2
Device|Other	2
Drug|Other	2
Behavioral|Device|placebo	1
Biological	1
Biological|Device	1
Combination Product	1
Device|Drug	1
Device|placebo	1
Drug|Other|Procedure	1
placebo|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	54
Korea, Republic of	16
Canada	9
NA	9
China	7
Sweden	4
Turkey	4
Netherlands	3
Switzerland	3
Czechia	2
Denmark	2
Israel	2
Taiwan	2
Australia	1
Australia|Belgium|France|Germany|Iceland|Italy|Poland|Singapore|Sweden|United Kingdom	1
Belgium	1
Belgium|Germany|United Kingdom	1
France	1
Germany	1
Germany|Hungary|Ireland|Spain|United Kingdom	1
Germany|Netherlands|Switzerland	1
Greece	1
Hong Kong	1
Norway	1
Spain	1
Thailand	1
United Kingdom	1
United States|Canada	1
United States|Puerto Rico	1

Sites per Study

Site_count	Study_Count
1	90
2	9
3	4
4	3
5	2
7	1
8	4
10	1
11	1
12	2
13	4
14	1
15	2
16	1
18	1
19	2
27	1
28	1
29	2
32	1

Phase

Phase	Study_Count
N/A	91
Phase 4	26
Phase 3	6
Phase 1/Phase 2	3
Phase 2	3
Early Phase 1	2
Phase 2/Phase 3	2

Number of Arms

Number_of_Arms	Count_of_Studies
1	24
2	89
3	11
4	3
6	2
NA	4

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	49.00	8.0000	6.00000	24	22.00	66.0000	17.0000
1st Qu.	96.75	55.5000	9.00000	24	27.75	112.5000	40.5000
Median	144.50	104.0000	12.00000	24	33.50	164.0000	68.5000
Mean	144.50	153.1319	34.66667	36	33.50	207.6667	106.5385
3rd Qu.	192.25	196.5000	49.00000	42	39.25	271.0000	149.0000
Max.	240.00	1000.0000	86.00000	60	45.00	450.0000	400.0000

Trial Group Type

group_type	Group_Count
Experimental	101
Active Comparator	98
Other	24
Placebo Comparator	17
No Intervention	16
NA	4
Sham Comparator	3

Intervention Model

intervention_model	Study_Count
Parallel Assignment	101
Single Group Assignment	28
Crossover Assignment	2
Factorial Assignment	1
NA	1

Primary Purpose

primary_purpose	Study_Count
Treatment	113
Prevention	8
Diagnostic	4
Other	4
Health Services Research	3
Supportive Care	1

Observational Studies

Studies by Country

Country	Study_Count
United States	14
Korea, Republic of	5
Switzerland	5
France	3
NA	3
Canada	2
Denmark	2
Netherlands	2
Norway	2
Turkey	2
China	1
Germany	1
Germany|Spain	1
Taiwan	1

Sites per Study

Site_count	Study_Count
1	34
2	3
3	2
5	3
7	1
601	1

Enrollment Metrics

Measure	Observational
Min	15.000
1st Qu	59.500
Median	110.000
Mean	2639.136
3rd Qu	255.000
Max	100000.000

Observation Model

observational_model	Study_Count
Cohort	34
Case-Only	4
Other	4
Case-Control	2

Time Perspective

time_perspective	Study_Count
Prospective	28
Retrospective	8
Other	5
Cross-Sectional	3

Registries

Studies by Country

Country	Study_Count
United States	6
Denmark	2
Austria|France|Germany|Netherlands|Switzerland	1
Canada	1
Italy	1
Korea, Republic of	1
NA	1

Sites per Study

Site_count	Study_Count
1	10
4	1
13	1
28	1

Enrollment Metrics

Measure	Registries
Min	20.000
1st Qu	100.000
Median	450.000
Mean	2044.154
3rd Qu	1665.000
Max	10000.000

Registry Model

observational_model	Study_Count
Cohort	9
Other	4

Time Perspective

time_perspective	Study_Count
Prospective	13

Follow-up

target_duration	Study_Count
2 Years	3
1 Year	2
60 Months	2
10 Years	1
12 Months	1
3 Months	1
5 Years	1
6 Months	1
8 Months	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03480893	Cost-effectiveness of Small Size Interarcuair Decompression Versus Extended Decompression in Patients With Intermittent Neurogenic Claudication	https://ClinicalTrials.gov/show/NCT03480893	Recruiting	Erasmus Medical Center	2022-04-01
NCT03388983	Effectiveness of Prehabilitation for Patients Undergoing Lumbar Spinal Stenosis Surgery	https://ClinicalTrials.gov/show/NCT03388983	Recruiting	The Hong Kong Polytechnic University	2021-12-31
NCT03381677	Pedicle Osteotomy for Stenosis Trial	https://ClinicalTrials.gov/show/NCT03381677	Recruiting	Innovative Surgical Designs	2022-10-26
NCT03368638	Physical Therapy Treatments, Including Neural Mobilization and Hip/Back Stretches for People Between 50-89 With Lumbar Spinal Stenosis and Leg Pain Provoked by Walking	https://ClinicalTrials.gov/show/NCT03368638	Active, not recruiting	Texas Tech University Health Sciences Center	2019-10-22
NCT04166981	Instr. vs. Non-instr. Posterolateral Spinal Fusion in Patients With Spinal Stenosis and Degenerative Listhesis	https://ClinicalTrials.gov/show/NCT04166981	Recruiting	Spine Centre of Southern Denmark	2021-09-01
NCT03337178	Fitbit Pilot Study in Post-operative Lumbar Degenerative Spinal Stenosis Patients	https://ClinicalTrials.gov/show/NCT03337178	Recruiting	The London Spine Centre	2019-08-31
NCT03302520	Comparison of Bioactive Glass Ceramics Spacer and PEEK Cages in Posterior Lumbar Interbody Fusion: A Prospective, RCT	https://ClinicalTrials.gov/show/NCT03302520	Active, not recruiting	Seoul National University Hospital	2019-07-11
NCT03302507	Biportal Endoscopy Spine Surgery (BESS )Versus Unilateral Laminotomy Bilateral Decompression (ULBD ): RCT, Non-inferiority Trial	https://ClinicalTrials.gov/show/NCT03302507	Completed	Seoul National University Hospital	2019-06-30
NCT03167736	Dry Needling and Spinal Manipulation vs. Conventional PT for Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT03167736	Recruiting	Alabama Physical Therapy & Acupuncture	2020-03-15
NCT03115983	LimiFlex Clinical Trial for the Treatment of Degenerative Spondylolisthesis With Spinal Stenosis	https://ClinicalTrials.gov/show/NCT03115983	Recruiting	Empirical Spine, Inc.	2020-12-31
NCT03105167	Cortical Bone Trajectory Screws vs. Traditional Pedicle Screws Fixation	https://ClinicalTrials.gov/show/NCT03105167	Recruiting	Second Affiliated Hospital of Wenzhou Medical University	2020-12-13
NCT03088306	Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients	https://ClinicalTrials.gov/show/NCT03088306	Completed	Johns Hopkins University	2018-05-31
NCT03047044	The Comparison of Postoperative Pain After Lumbar Fusion Surgery in Intravenous Patient-controlled Analgesia Between Conventional Mode and Optimizing B.I Mode With ‘PAINSTOP’ Equipment	https://ClinicalTrials.gov/show/NCT03047044	Completed	Yonsei University	2019-01-30
NCT03012776	A Pivotal Study of the Premia Spine TOPSâ„¢ System	https://ClinicalTrials.gov/show/NCT03012776	Recruiting	Premia Spine	2020-09-30
NCT02939482	A Study Comparison of Clinical Outcome After Different Rate of Infusion in Caudal Epidural Steroid Injection	https://ClinicalTrials.gov/show/NCT02939482	Completed	Navamindradhiraj University	2018-08-02
NCT02902380	The Effect of Dexmedetomidine on Neuroendocrine Stress Hormone Release and Heart Rate Variability in Patients Undergoing Major Spinal Surgery	https://ClinicalTrials.gov/show/NCT02902380	Completed	Yonsei University	2017-07-01
NCT02895555	The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumentated Posterolateral Fusionin The IVANOS-study	https://ClinicalTrials.gov/show/NCT02895555	Completed	Sygehus Lillebaelt	2016-01-31
NCT02838615	Comparison of Transforaminal vs. Parasagittal Interlaminar Epidural Injection	https://ClinicalTrials.gov/show/NCT02838615	Completed	Keimyung University Dongsan Medical Center	2017-05-31
NCT02826889	Assessing the Diagnostic Accuracy of Corrected Flow Time (FTc) and Pleth Variability Index (PVI) as Predictors of Fluid Responsiveness in Patients in the Prone Position Using the Jackson Table	https://ClinicalTrials.gov/show/NCT02826889	Completed	Yonsei University	2017-07-27
NCT02700451	Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes	https://ClinicalTrials.gov/show/NCT02700451	Active, not recruiting	Hospital for Special Surgery, New York	2020-12-31
NCT02697435	Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)	https://ClinicalTrials.gov/show/NCT02697435	Completed	VA Office of Research and Development	2018-05-31
NCT02625194	The Utility of Oxygen Insufflation During Flexible Fiberoptic Bronchoscope-guided Intubation	https://ClinicalTrials.gov/show/NCT02625194	Completed	Yonsei University	2017-09-04
NCT02592642	the Evaluation of Four Non-operative Treatments for Degenerative Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT02592642	Completed	Mount Sinai Hospital, Canada	2017-02-15
NCT02558621	New Robotic Assistance System for Spinal Fusion Surgery	https://ClinicalTrials.gov/show/NCT02558621	Completed	KB Medical SA	2016-05-31
NCT02555280	Post-Approval ‘Real Conditions of Use’ Study	https://ClinicalTrials.gov/show/NCT02555280	Recruiting	Paradigm Spine	2024-09-30
NCT01106417	Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion	https://ClinicalTrials.gov/show/NCT01106417	Completed	Mesoblast, Ltd.	2012-05-31
NCT02464553	EuroPainClinics® Study I (Prospective Trial)	https://ClinicalTrials.gov/show/NCT02464553	Recruiting	Europainclinics z.ú.	2021-05-31
NCT02459392	EuroPainClinics® Study II (Prospective Trial)	https://ClinicalTrials.gov/show/NCT02459392	Recruiting	Europainclinics z.ú.	2021-11-30
NCT02444351	Botulinum Toxin Type A Injection Into the Gastrocnemius Muscle for Treatment of Nocturnal Calf Cramps in Patients With Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT02444351	Completed	Yonsei University	2016-06-30
NCT02348645	Decompression vs. Fusion for Stable Degenerative Spondylolisthesis	https://ClinicalTrials.gov/show/NCT02348645	Recruiting	University Health Network, Toronto	2022-06-30
NCT02341950	Clinical Trial of a Serious Game for Individuals With SCI/D	https://ClinicalTrials.gov/show/NCT02341950	Completed	University of Michigan	2017-09-01
NCT02300909	dHACM in Lumbar Decompression and Microdiscectomy Surgery	https://ClinicalTrials.gov/show/NCT02300909	Completed	MiMedx Group, Inc.	2018-06-30
NCT02271191	Effect of Nicardipine on Renal Function in Deliberate Hypotension	https://ClinicalTrials.gov/show/NCT02271191	Completed	Yonsei University	2013-01-31
NCT02260401	Long Term Outcomes of Lumbar Epidural Steroid Injections for Spinal Stenosis	https://ClinicalTrials.gov/show/NCT02260401	Completed	University of Washington	2015-07-31
NCT02258672	Preoperative Rehabilitation for Patients Undergoing Surgery for Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT02258672	Completed	Université du Québec à Trois-Rivières	2020-03-01
NCT02254590	Irrigation Endoscopic Decompression	https://ClinicalTrials.gov/show/NCT02254590	Completed	Cairo University	2014-03-31
NCT02252185	A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery	https://ClinicalTrials.gov/show/NCT02252185	Completed	Johnson & Johnson Medical (Suzhou) Ltd.	2015-09-30
NCT02127008	The Impact of Epidural Fat Resection on Postoperative Outcomes in Posterior Surgery of Lumbar Spine	https://ClinicalTrials.gov/show/NCT02127008	Completed	Seoul National University Hospital	2014-05-31
NCT02121249	Clinical Trial of Minimally Invasive Robotic Spine Surgery	https://ClinicalTrials.gov/show/NCT02121249	Completed	Seoul National University Hospital	2014-04-30
NCT02093520	The MiDAS ENCORE Study	https://ClinicalTrials.gov/show/NCT02093520	Completed	Vertos Medical, Inc.	2016-05-31
NCT02090244	Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans?	https://ClinicalTrials.gov/show/NCT02090244	Completed	University Hospital, Linkoeping	2018-05-31
NCT02079038	The STEPS - Totalisâ„¢ Trial	https://ClinicalTrials.gov/show/NCT02079038	Completed	VertiFlex, Incorporated	2017-01-31
NCT02063035	Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery	https://ClinicalTrials.gov/show/NCT02063035	Completed	Massachusetts General Hospital	2015-04-22
NCT01316211	Clinical Trial Comparing Decompression With and Without Coflexâ„¢ Interlaminar Technology Treating Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT01316211	Completed	Paradigm Spine	2014-08-31
NCT01315145	MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study	https://ClinicalTrials.gov/show/NCT01315145	Completed	Vertos Medical, Inc.	2014-05-31
NCT01275547	The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam	https://ClinicalTrials.gov/show/NCT01275547	Completed	University Hospital, Basel, Switzerland	2011-06-30
NCT02023372	Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine	https://ClinicalTrials.gov/show/NCT02023372	Completed	NuTech Medical, Inc	2019-08-16
NCT02039232	Safety and Efficacy of the CarboFix Pedicle Screw System	https://ClinicalTrials.gov/show/NCT02039232	Completed	CarboFix Orthopedics Ltd.	2017-08-31
NCT02007083	The NORDSTEN Studies/ The Spinal Stenosis Study	https://ClinicalTrials.gov/show/NCT02007083	Active, not recruiting	Haukeland University Hospital	2025-10-31
NCT01994512	Swedish Spinal Stenosis Study	https://ClinicalTrials.gov/show/NCT01994512	Completed	Uppsala University	2012-06-30
NCT01991912	Irrigation Endoscopic Decompressive Laminotomy	https://ClinicalTrials.gov/show/NCT01991912	Completed	Cairo University	2012-06-30
NCT01987622	Acupuncture for Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT01987622	Completed	Korean Medicine Hospital of Pusan National University	2014-09-30
NCT01968993	Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spine	https://ClinicalTrials.gov/show/NCT01968993	Completed	Pioneer Surgical Technology, Inc.	2015-10-31
NCT01943435	Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)	https://ClinicalTrials.gov/show/NCT01943435	Completed	University of Pittsburgh	2016-06-07
NCT01934868	Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg	https://ClinicalTrials.gov/show/NCT01934868	Active, not recruiting	Hadassah Medical Organization	2021-04-30
NCT01921530	Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis	https://ClinicalTrials.gov/show/NCT01921530	Recruiting	The London Spine Centre	2018-12-31
NCT01888536	A Study to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT01888536	Completed	Yungjin Pharm. Co., Ltd.	2013-10-31
NCT01829997	Assessment of nanOss Bioactive 3D in the Posterolateral Spine	https://ClinicalTrials.gov/show/NCT01829997	Completed	Pioneer Surgical Technology, Inc.	2018-04-30
NCT01727752	A Randomized Controlled Trial Comparing Surgical Decompression With an Interlaminar Implant in Patients With Intermittent Neurogenic Claudication Caused by Lumbar Stenosis	https://ClinicalTrials.gov/show/NCT01727752	Completed	Paradigm Spine	2015-06-30
NCT01455805	Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT01455805	Active, not recruiting	Spinal Simplicity LLC	2024-03-31
NCT00996073	Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion	https://ClinicalTrials.gov/show/NCT00996073	Completed	Mesoblast, Ltd.	2012-07-31
NCT00549913	Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF)	https://ClinicalTrials.gov/show/NCT00549913	Completed	Mesoblast, Ltd.	2013-08-31
NCT04403360	Erector Spinae Plane Block After Lumbar Spinal Stenosis Surgery	https://ClinicalTrials.gov/show/NCT04403360	Recruiting	Clinique Saint Pierre Ottignies	2020-12-31
NCT04401735	Effects and Safety of Epidural PDRN vs. Placebo	https://ClinicalTrials.gov/show/NCT04401735	Recruiting	Seoul National University Hospital	2020-05-31
NCT04391855	Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Plus Ropivacaine for Pain Relief After Spine Surgery	https://ClinicalTrials.gov/show/NCT04391855	Recruiting	Aristotle University Of Thessaloniki	2020-11-30
NCT04330885	PRE Surgery reHABilitation for Spinal Stenosis	https://ClinicalTrials.gov/show/NCT04330885	Recruiting	Karolinska Institutet	2020-12-31
NCT04254757	Percutaneous Endoscopic Decompression for Lumbar Canal Stenosis	https://ClinicalTrials.gov/show/NCT04254757	Recruiting	Peking University Third Hospital	2021-12-31
NCT04204720	A Comparison of Intravascular Injection With Chiba Needle and Whitacre Needle	https://ClinicalTrials.gov/show/NCT04204720	Completed	Kyungpook National University Hospital	2019-12-15
NCT04193488	Mid-Transverse Process to Pleural (MTP) Block and Erector Spinal Plan (ESP) Block in Spinal Surgery	https://ClinicalTrials.gov/show/NCT04193488	Completed	Gulhane School of Medicine	2020-01-01
NCT04192591	A 5-year Superion® IDS Clinical Outcomes Post-Approval Evaluation (SCOPE)	https://ClinicalTrials.gov/show/NCT04192591	Recruiting	Boston Scientific Corporation	2024-01-31
NCT04189341	Modified-Thoracolumbar Interfascial Plane Block and Erector Spinae Plane Block Following Lumbar Instrumentation Surgery	https://ClinicalTrials.gov/show/NCT04189341	Recruiting	Medipol University	2020-08-30
NCT04094220	LLIF Plus Posterior Decompression for Severe Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT04094220	Recruiting	Second Affiliated Hospital, School of Medicine, Zhejiang University	2021-08-01
NCT04087694	Microdecompression Versus Open Laminectomy and Posterior Stabilization for Multilevel Lumbar Spine Stenosis	https://ClinicalTrials.gov/show/NCT04087694	Completed	Hawler Medical University	2018-10-04
NCT04075539	Home-based Cycling for People With Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT04075539	Recruiting	Assistance Publique - Hôpitaux de Paris	2022-10-31
NCT04062474	Epidural Intervention of Spinal Nerves With Tumor Necrosis Factor-Alpha Inhibitor	https://ClinicalTrials.gov/show/NCT04062474	Completed	Nanjing First Hospital, Nanjing Medical University	2016-12-15
NCT04042948	Clinical Effect of Preventive Use of Tylenol on Fever After Removal of Drainage Tube in Lumbar Fusion Surgery	https://ClinicalTrials.gov/show/NCT04042948	Recruiting	Peking University Third Hospital	2020-05-28
NCT04007094	Single-Armed Use of ViviGen Cellular Bone Matrix in Patients Undergoing Posterolateral Lumbar Surgery	https://ClinicalTrials.gov/show/NCT04007094	Recruiting	Ohio State University	2021-12-31
NCT03968965	Evaluation of 3D Machine-vision Image Guided Surgery Spine Navigation	https://ClinicalTrials.gov/show/NCT03968965	Recruiting	7D Surgical Inc.	2020-12-31
NCT03958526	Effectiveness of Transcranial Direct Current Stimulation in Chronic Pain Related to Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT03958526	Recruiting	Istanbul University	2019-09-30
NCT03884283	Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT	https://ClinicalTrials.gov/show/NCT03884283	Enrolling by invitation	Prosidyan, Inc.	2021-02-28
NCT03883022	Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery	https://ClinicalTrials.gov/show/NCT03883022	Recruiting	Taipei Veterans General Hospital, Taiwan	2027-09-12
NCT03863067	Clinical Effectiveness, Security And Radiological Changes In Epiduroscopy For Lumbar Stenosis	https://ClinicalTrials.gov/show/NCT03863067	Recruiting	Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz	2019-10-15
NCT03801356	Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy	https://ClinicalTrials.gov/show/NCT03801356	Recruiting	The Cleveland Clinic	2020-08-23
NCT03784729	Efficacy of Acupuncture for Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT03784729	Recruiting	Guang’anmen Hospital of China Academy of Chinese Medical Sciences	2020-06-30
NCT03754972	Sagittal Plane Shear Index for Planning Lumbar Stenosis Surgery	https://ClinicalTrials.gov/show/NCT03754972	Recruiting	Medical Metrics Diagnostics, Inc	2020-03-31
NCT03753945	Spine MRI in Patients With Deep Brain Stimulation (DBS)	https://ClinicalTrials.gov/show/NCT03753945	Recruiting	University Health Network, Toronto	2021-01-01
NCT03745040	Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion	https://ClinicalTrials.gov/show/NCT03745040	Recruiting	Allina Health System	2020-11-30
NCT03733626	Clinical Outcomes Associated With the Use of ViviGen® for the Treatment of Lumbar Degenerative Disc Disease	https://ClinicalTrials.gov/show/NCT03733626	Active, not recruiting	William Beaumont Hospitals	2022-11-01
NCT03647501	Lumbar Fusion With Nexxt Spine 3D-Printed Titanium Interbody Cages	https://ClinicalTrials.gov/show/NCT03647501	Recruiting	Ohio State University	2022-08-01
NCT03610737	The MOTION Study - Treatment of LSS With the MILD Procedure	https://ClinicalTrials.gov/show/NCT03610737	Active, not recruiting	Vertos Medical, Inc.	2020-07-30
NCT03570801	SLIP II Registry: Spinal Laminectomy Versus Instrumented Pedicle Screw Fusion	https://ClinicalTrials.gov/show/NCT03570801	Recruiting	Lahey Clinic	2021-10-31
NCT03560401	Is Postoperative Bracing Necessary After Spine Surgery for Degenerative Conditions	https://ClinicalTrials.gov/show/NCT03560401	Completed	Taipei Veterans General Hospital, Taiwan	2016-12-25
NCT03553186	Tranexamic Acid in Adult Spinal Deformity Surgery	https://ClinicalTrials.gov/show/NCT03553186	Recruiting	Hospital for Special Surgery, New York	2021-05-31
NCT03532945	A Follow-up Study to Evaluate the Efficacy and Safety of Novomax in Posterior Lumbar Interbody Fusion	https://ClinicalTrials.gov/show/NCT03532945	Completed	BioAlpha Inc.	2013-09-13
NCT03511053	Epidural Lavage Study	https://ClinicalTrials.gov/show/NCT03511053	Active, not recruiting	Dallas VA Medical Center	2020-07-18
NCT03495661	Decompression vs Physical Training for the Treatment of Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT03495661	Recruiting	Uppsala University	2021-12-31
NCT01263678	Helping Patients With Spinal Stenosis Make a Treatment Decision: A Randomized Study Assessing The Benefits of Health Coaching	https://ClinicalTrials.gov/show/NCT01263678	Completed	Dartmouth-Hitchcock Medical Center	2013-05-31
NCT01238536	Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)	https://ClinicalTrials.gov/show/NCT01238536	Completed	University of Washington	2013-08-31
NCT01131611	Cognitive-Behavioral Physical Therapy	https://ClinicalTrials.gov/show/NCT01131611	Completed	Vanderbilt University	2014-04-30
NCT01127100	Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic Pain	https://ClinicalTrials.gov/show/NCT01127100	Completed	Seoul National University Hospital	2011-11-30
NCT01097486	Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy	https://ClinicalTrials.gov/show/NCT01097486	Completed	Mesoblast, Ltd.	2013-07-31
NCT01082159	MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study	https://ClinicalTrials.gov/show/NCT01082159	Completed	Vertos Medical, Inc.	2012-10-31
NCT01076244	Vertos Mild - Post Market Patient Outcomes	https://ClinicalTrials.gov/show/NCT01076244	Completed	The Center for Pain Relief, Inc.	2012-01-31
NCT01052324	The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation	https://ClinicalTrials.gov/show/NCT01052324	Completed	Yonsei University	2010-11-30
NCT00995371	Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis	https://ClinicalTrials.gov/show/NCT00995371	Completed	Coastal Orthopedics & Sports Medicine	2012-06-30
NCT00956631	MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study	https://ClinicalTrials.gov/show/NCT00956631	Completed	Vertos Medical, Inc.	2012-04-30
NCT00939406	Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy	https://ClinicalTrials.gov/show/NCT00939406	Completed	AO Innovation Translation Center	2012-11-30
NCT00908375	Efficacy of Pregabalin in Patients With Radicular Pain	https://ClinicalTrials.gov/show/NCT00908375	Completed	Northwestern University	2012-09-30
NCT00905359	Neurogenic Intermittent Claudication Evaluation Study	https://ClinicalTrials.gov/show/NCT00905359	Completed	Medtronic Spinal and Biologics	2014-09-30
NCT00887744	Intermittent Neurogenic Claudication Treatment With APERIUS®	https://ClinicalTrials.gov/show/NCT00887744	Completed	Medtronic Spinal and Biologics	2009-05-31
NCT01452022	Performance of Inductigraft in Spinal Fusion	https://ClinicalTrials.gov/show/NCT01452022	Completed	Baxter Healthcare Corporation	2015-08-31
NCT00808665	Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion	https://ClinicalTrials.gov/show/NCT00808665	Completed	Vanderbilt University Medical Center	2012-12-31
NCT02644746	Efficacy and Safety of Acupuncture for Degenerative Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT02644746	Completed	Guang’anmen Hospital of China Academy of Chinese Medical Sciences	2017-12-31
NCT02454400	Pre-surgery Physiotherapy for Patients With Specific Low Back Pain	https://ClinicalTrials.gov/show/NCT02454400	Completed	Linkoeping University	2017-10-31
NCT02416804	Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery	https://ClinicalTrials.gov/show/NCT02416804	Completed	Seoul National University Hospital	2016-07-31
NCT04039581	KT® in Patients With Cervical Spine Surgery	https://ClinicalTrials.gov/show/NCT04039581	Active, not recruiting	Marmara University	2020-07-31
NCT03969602	Cognitive Behavioral Therapy (CBT) After Lumbar Spinal Fusion in Patients With High Pain Catastrophizing	https://ClinicalTrials.gov/show/NCT03969602	Recruiting	Neurocenter of Southern Switzerland	2023-07-30
NCT00786981	Epidural Steroid Injection Versus Epidural Steroid Injection and Manual Physical Therapy and Exercise in the Management of Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT00786981	Completed	Franklin Pierce University	2018-12-31
NCT00749073	The Vertos MILDâ„¢ Preliminary Patient Evaluation Study	https://ClinicalTrials.gov/show/NCT00749073	Completed	Vertos Medical, Inc.	2009-07-31
NCT00692276	Investigating Superionâ„¢ In Spinal Stenosis	https://ClinicalTrials.gov/show/NCT00692276	Completed	VertiFlex, Incorporated	2017-02-28
NCT00638443	Lumbar Stenosis Outcomes Research (LUSTOR)	https://ClinicalTrials.gov/show/NCT00638443	Completed	University of Rochester	2010-03-31
NCT00534235	Post-Approval Clinical Trial Comparing the Long Term Safety and Effectiveness Coflex vs. Fusion to Treat Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT00534235	Completed	Paradigm Spine	2015-12-31
NCT00527527	Chiropractic Dosage for Lumbar Stenosis	https://ClinicalTrials.gov/show/NCT00527527	Completed	National University of Health Sciences	2010-01-31
NCT00493558	Spine Research With Roentgen Stereophotogrammetric Analysis	https://ClinicalTrials.gov/show/NCT00493558	Completed	Nova Scotia Health Authority	2012-06-30
NCT00405691	Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis	https://ClinicalTrials.gov/show/NCT00405691	Completed	Impliant, Ltd.	NA
NCT00405600	Spine Fusion Instrumented With BMP-2 vs Uninstrumented With Infuse BMP-2 Alone	https://ClinicalTrials.gov/show/NCT00405600	Completed	Nova Scotia Health Authority	2010-12-31
NCT00401518	A Pivotal Study of a Facet Replacement System to Treat Spinal Stenosis	https://ClinicalTrials.gov/show/NCT00401518	Completed	Globus Medical Inc	2017-08-31
NCT00370799	Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain	https://ClinicalTrials.gov/show/NCT00370799	Completed	Pain Management Center of Paducah	2009-12-31
NCT00320619	Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine Surgery	https://ClinicalTrials.gov/show/NCT00320619	Completed	National Heart, Lung, and Blood Institute (NHLBI)	2006-02-28
NCT00109213	Greenwich Lumbar Stenosis SLIP Study	https://ClinicalTrials.gov/show/NCT00109213	Completed	Greenwich Hospital	2009-09-30
NCT00022776	Surgical Versus Nonsurgical Treatment for Spinal Stenosis	https://ClinicalTrials.gov/show/NCT00022776	Completed	University of Pittsburgh	2007-12-31
NCT00000411	Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis	https://ClinicalTrials.gov/show/NCT00000411	Completed	Dartmouth-Hitchcock Medical Center	2015-04-30
NCT00000409	Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis	https://ClinicalTrials.gov/show/NCT00000409	Completed	Dartmouth-Hitchcock Medical Center	2015-04-30

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03325309	Barriers and Facilitators to Cycling for Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT03325309	Completed	Assistance Publique - Hôpitaux de Paris	2016-12-21
NCT03321357	Retest-reliability and At-home-assessment Feasibility of the 5R-STS	https://ClinicalTrials.gov/show/NCT03321357	Completed	Bergman Clinics	2018-06-01
NCT03303300	The Five-repetition Sit-to-stand Test for Lower Back Pain or Radiculopathy	https://ClinicalTrials.gov/show/NCT03303300	Completed	Bergman Clinics	2017-12-01
NCT03194607	Quantitative Evaluation of Motor Function Before and After Surgery for Degenerative Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT03194607	Recruiting	Centre Hospitalier Universitaire Dijon	2019-05-31
NCT03041896	Retrospective Evaluation of Performance of Coflex® Interlaminer Technology Versus Decompression With or Without Fusion	https://ClinicalTrials.gov/show/NCT03041896	Completed	Paradigm Spine	2017-12-31
NCT02931279	PASS OCT® Post-market Clinical Follow-up	https://ClinicalTrials.gov/show/NCT02931279	Recruiting	Medicrea International	2019-09-30
NCT02761928	Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients	https://ClinicalTrials.gov/show/NCT02761928	Active, not recruiting	The University of Texas Health Science Center, Houston	2025-12-31
NCT03072927	MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study	https://ClinicalTrials.gov/show/NCT03072927	Recruiting	Vertos Medical, Inc.	2022-12-31
NCT02529943	Changes in Motor Latency During Spinal Decompression: Relationship to Outcomes	https://ClinicalTrials.gov/show/NCT02529943	Recruiting	University of Saskatchewan	2021-10-31
NCT02257723	The Effect of Integrated CAM Treatment in Hospitalized Patients	https://ClinicalTrials.gov/show/NCT02257723	Recruiting	Jaseng Hospital of Korean Medicine	2030-12-31
NCT02215551	Predictors of Decompressive Laminectomy Outcomes	https://ClinicalTrials.gov/show/NCT02215551	Active, not recruiting	VA Office of Research and Development	2019-07-01
NCT02134821	Influence of Pain Sensitivity on Lumbar Surgery Outcomes	https://ClinicalTrials.gov/show/NCT02134821	Completed	Seoul National University Hospital	2014-04-30
NCT02064855	Evaluation of Fusion Rate Using K2M VESUVIUS® Demineralized Fibers With K2M EVEREST® Spinal System	https://ClinicalTrials.gov/show/NCT02064855	Enrolling by invitation	K2M, Inc.	2020-03-31
NCT02006901	Comparative Effectiveness of Microdecompression and Laminectomy for Central Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT02006901	Completed	St. Olavs Hospital	2015-01-31
NCT01972256	A Study Comparing Fusion Rates of Two Lumbar Fusion Procedures	https://ClinicalTrials.gov/show/NCT01972256	Completed	Baxano Surgical, Inc.	2014-02-28
NCT01485289	Stabilimax Investigational Device Exemption (IDE) Clinical Investigation Patient Followup Study	https://ClinicalTrials.gov/show/NCT01485289	Completed	Rachiotek LLC	2012-11-30
NCT03898232	Fibergraft Interbody Fusion Retrospective	https://ClinicalTrials.gov/show/NCT03898232	Enrolling by invitation	Bone and Joint Clinic of Baton Rouge	2020-04-30
NCT04444739	Association Between Lumbar Muscle Atrophy, Sagittal Pelvic Alignment and Stenosis Grade in Patients With Degenerative Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT04444739	Recruiting	University Hospital, Basel, Switzerland	2021-02-28
NCT04443738	Long Term Follow up of Spinal Stenosis Inpatients Treated With Korean Integrative Medicine Treatment.	https://ClinicalTrials.gov/show/NCT04443738	Recruiting	Jaseng Medical Foundation	2020-08-15
NCT04381663	CSS-Assessing the Course of Degenerative Cervical Spinal Stenosis Using Functional Outcomes	https://ClinicalTrials.gov/show/NCT04381663	Enrolling by invitation	University Hospital, Basel, Switzerland	2022-03-15
NCT04379765	Long-term Follow-up of Conservative and Surgical Treatment Results of Patients With Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT04379765	Recruiting	Sisli Hamidiye Etfal Training and Research Hospital	2021-04-15
NCT04315090	Post-surgical Outcomes Measure Using the ERAS Protocol for Posterior Cervical Decompression and Fusion	https://ClinicalTrials.gov/show/NCT04315090	Recruiting	Mayo Clinic	2022-05-01
NCT04314453	Comparisons Therapeutic Effects of Different PELD Procedure on LSS.	https://ClinicalTrials.gov/show/NCT04314453	Completed	Second Affiliated Hospital of Wenzhou Medical University	2017-07-31
NCT04216992	Value of Three-dimensional Rotational Epidurography on Percutaneous Epidural Adhesiolysis	https://ClinicalTrials.gov/show/NCT04216992	Completed	Tri-Service General Hospital	2019-10-24
NCT04171544	Streamline Occipito-Cervico-Thoracic System Post-Market Clinical Follow-up	https://ClinicalTrials.gov/show/NCT04171544	Enrolling by invitation	RTI Surgical	2020-03-31
NCT04086784	3D-printed Porous Titanium Alloy Cages Versus PEEK Cages in Patients With Osteoporosis	https://ClinicalTrials.gov/show/NCT04086784	Enrolling by invitation	Peking University Third Hospital	2022-12-31
NCT04062942	The Six-Minute Walking Test (6WT) and Timed-Up-and-Go (TUG) Test as Measures of Objective Functional Impairment in Patients Undergoing Interlaminar or Transforaminal Epidural Steroid Injection for Lumbar Degenerative Disc Disease (DDD)	https://ClinicalTrials.gov/show/NCT04062942	Recruiting	Cantonal Hospital of St. Gallen	2020-07-15
NCT04058171	Validation of a Treadmill Walking Test to Discriminate Neurogenic Claudication From Vascular Claudication	https://ClinicalTrials.gov/show/NCT04058171	Recruiting	Université du Québec à Trois-Rivières	2020-12-30
NCT03977961	The Six-Minute Walking Test (6MWT) as a Measure of Functional Impairment in Lumbar Degenerate Disc Disease.	https://ClinicalTrials.gov/show/NCT03977961	Recruiting	Cantonal Hospital of St. Gallen	2020-05-01
NCT03956537	PMCF Neo Pedicle Screw and Cage Systems	https://ClinicalTrials.gov/show/NCT03956537	Recruiting	Neo Medical SA	2022-04-30
NCT03951935	Muscle Function and Pelvic Stability While Walking in Patients With Symptomatic Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT03951935	Recruiting	University Hospital, Basel, Switzerland	2021-06-30
NCT03923920	Screening for Systemic Amyloidosis Via the Ligamentum Flavum	https://ClinicalTrials.gov/show/NCT03923920	Recruiting	The Cleveland Clinic	2021-04-01
NCT03910335	Diagnostic Screening Tool for Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT03910335	Completed	University of Southern Denmark	2019-06-28
NCT03891745	Prone or Supine Extubation in Lomber Spinal Surgery	https://ClinicalTrials.gov/show/NCT03891745	Recruiting	Istanbul Medeniyet University	2019-07-01
NCT03863769	Chiropractic Distraction Spinal Manipulation- Lumbar Stenosis Study	https://ClinicalTrials.gov/show/NCT03863769	Recruiting	Parker University	2020-12-31
NCT03853356	Evidence For Fusion In Spine With Orthoss®	https://ClinicalTrials.gov/show/NCT03853356	Recruiting	Geistlich Pharma AG	2021-09-30
NCT03562936	The NORDSTEN Studies/The Observational Cohort Study	https://ClinicalTrials.gov/show/NCT03562936	Recruiting	Haukeland University Hospital	2018-10-01
NCT03532230	Cost Effectiveness of OMT for Chronic Low Back Pain	https://ClinicalTrials.gov/show/NCT03532230	Completed	Rowan University	2020-02-28
NCT01017692	Magnetic Resonance Imaging (MRI) Interpretations for Lumbar Spinal Stenosis (LSS)	https://ClinicalTrials.gov/show/NCT01017692	Completed	State University of New York - Upstate Medical University	2010-12-31
NCT01522846	Heparin Solution and INTEM/HEPTEM Analysis	https://ClinicalTrials.gov/show/NCT01522846	Completed	Seoul National University Bundang Hospital	2013-01-31
NCT02836730	Long-term Outcomes of Surgical and Nonsurgical Management of Sciatica Secondary to a Lumbar Disc Herniation or Spinal Stenosis	https://ClinicalTrials.gov/show/NCT02836730	Completed	Back and Rehabilitation Center, Copenhagen	2016-01-31
NCT03879447	Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/Spondylolisthesis	https://ClinicalTrials.gov/show/NCT03879447	Recruiting	Jaseng Medical Foundation	2020-12-31
NCT00726284	Spine Patient Outcomes Registry for Biomet/EBI (Electro-Biology, Inc)	https://ClinicalTrials.gov/show/NCT00726284	Completed	Zimmer Biomet	2007-12-06
NCT00534092	Long-Term Outcomes for Lumbar Spinal Stenosis Patients Treated With X STOP®	https://ClinicalTrials.gov/show/NCT00534092	Completed	Medtronic Spinal and Biologics	NA

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03398915	The European Robotic Spinal Instrumentation (EUROSPIN) Study	https://ClinicalTrials.gov/show/NCT03398915	Recruiting	Bergman Clinics	2021-09-01
NCT03064802	Burst Biologics Spinal Fusion Registry	https://ClinicalTrials.gov/show/NCT03064802	Recruiting	Smart-Surgical Inc. dba Burst Biologics	2020-06-30
NCT02897947	Outcome of Surgery for Lumbar Spinal Stenosis - a Comparison of Data From Three National Quality Registries	https://ClinicalTrials.gov/show/NCT02897947	Completed	St. Olavs Hospital	2013-12-31
NCT02457468	The Coflex®COMMUNITY Study: An Observational Study of Coflex® Interlaminar Technology	https://ClinicalTrials.gov/show/NCT02457468	Completed	Predicted, Reported and Observed Outcomes Foundation	2019-12-31
NCT04250753	Assessment of Gait Parameters and Their Impact on Postoperative Recovery in Patients With Lumbar Spinal Stenosis: a Feasibility Study	https://ClinicalTrials.gov/show/NCT04250753	Recruiting	Université du Québec à Trois-Rivières	2020-11-01
NCT04176562	Prospective SPINE Registry	https://ClinicalTrials.gov/show/NCT04176562	Recruiting	RTI Surgical	2025-03-31
NCT04087811	Postmarket Registry for Evaluation of the Superion® Spacer	https://ClinicalTrials.gov/show/NCT04087811	Active, not recruiting	Boston Scientific Corporation	2020-12-31
NCT04079894	Developing an Instrument for Measuring Walking Ability in Patients With Spinal Stenosis	https://ClinicalTrials.gov/show/NCT04079894	Recruiting	Spine Centre of Southern Denmark	2022-01-31
NCT03644407	Galeazzi Spine Surgery RegistryGaleazzi Spine Registry: Prospective Study for Clinical Monitoring	https://ClinicalTrials.gov/show/NCT03644407	Recruiting	Istituto Ortopedico Galeazzi	2025-01-01
NCT03434223	Prospective Follow-up of Elderly Patients Undergoing Instrumented Lumbar Arthrodesis Supplemented by the Implanet Jazz System(TM)	https://ClinicalTrials.gov/show/NCT03434223	Recruiting	Ohio State University	2021-12-01
NCT03548441	Comparative Effectiveness and Prognostic Factors of Surgical and Non-surgical Management of Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT03548441	Recruiting	Spine Centre of Southern Denmark	2020-09-30
NCT04374669	Sarcopenia and Outcomes of Neuroplasty in Lumbar Spinal Stenosis	https://ClinicalTrials.gov/show/NCT04374669	Recruiting	Asan Medical Center	2021-05-31
NCT02411799	Instrumented Thoracic and Lumbar Arthrodesis Supplemented by the Implanet Jazz SystemTMd	https://ClinicalTrials.gov/show/NCT02411799	Recruiting	Ohio State University	2020-04-30